Sandy Creek is a tributary of the Ohio River in western West Virginia in the United States. Via the Ohio River, it is part of the watershed of the Mississippi River, draining an area of 124 square miles (321 km²) on the unglaciated portion of the Allegheny Plateau. According to the Geographic Names Information System, it has also been known historically as Big Sandy Creek and as Buffalo Creek.[5] A 1906 report of the West Virginia Department of Archives transcribes the name in an unspecified Native American language as Mol-chu-con-ic-kon.[6]